No. I use state-of-the-art virtual instruments for everything except strings (and often percussion). The purist may wince, but in a lot of situations its hard for even a trained ear to tell the difference when the modules are used to their full potential. The modules I currently use are BFD2 (Drums), Real Guitar, Trilian Bass, First Call Horns (brass and saxes), the many sounds and synths of Logic Pro 9 (Mac), and various Non-Royalty samples as required for specific projects.